子宫内膜异位症sICAM

子宫内膜异位症sICAM

【关键词】 子宫内膜异位症
Changes of sICAM1 and sHLAⅠin endometriosis and its significance
　　【Abstract】 AIM: To investigate the relationship between endometriosis (EMs) and the levels of soluble intercellular adhesion molecule1 (sICAM1) and soluble human leucocyte antigen1 (sHLAⅠ). METHODS: Thirty serum and 30 peritoneal fluid (PF) of patients with EMs (test group) and 30 serum and 30 peritoneal fluid of patients without EMs (control group) were studied. The levels of sICAM1 and sHLAⅠwere detected by enzymelinked immunosorbent assay (ELISA). RESULTS: ① Significantly higher levels of sICAM1 in serum and PF were observed in patients with EMs compared with those in controls (P0.05). ② The levels of sICAM1 in serum and PF were significantly different and the levels in earlystage EMs group were higher than those in advanced group (P0.05). ③ Serum sHLAⅠ cevel was lower in EMs group (P0.05) but the level in earlystage EMs group was higher than that in advanced group (P0.05). ④ There were no statistically significant differences in the levels of sHLAⅠin PF between the patients and the controls (P0.05). CONCLUSION: Changes of sICAM1and sHLAⅠmay play a role in the genesis of endometriosis.
　　【Keywords】 endometriosis; HLA antigens; intercellular adhesion molecule1; enzymelinked immunosorbent assay
　　【摘要】 目的： 探讨盆腔子宫内膜异位症（内异症）患者血清和腹腔液中可溶性细胞间粘附分子1(sICAM1)、可溶性人类白细胞抗原Ⅰ(sHLAⅠ)的水平与该病的发病关系. 方法： 以ELISA法定量检测sICAM1的水平、半定量检测sHLAⅠ水平. 结果： 内异症组血清和腹腔液中sICAM1和sHLAⅠ水平明显高于对照组(P