锰对PC12细胞生长增殖及对ERK信号转导通路的影响
作者：李妍，陈景元，蔡同建，郑刚，杜可军，骆文静【关键词】 MnCl2；大鼠；嗜铬细胞瘤PC12细胞；p
【Abstract】 AIM: To study the toxicity of different doses of MnCl2 on rat pheochromocytoma PC12 cells in vitro and their effects on signal transduction of extracellular signalregulated kinase 1/2 (ERK1/2). METHODS: PC12 cell cultures were exposed to MnCl2 within the range of 100900 μmol/L. The inhibition of the cells during 7 d was determined by MTT assay and plate clone formation test, and ERK1/2 and pERK1/2 were determined by Western blot. RESULTS: MnCl2 at different concentrations (100, 300, 500, 700 and 900 μmol/L) could inhibit the growth and proliferation of PC12 cells in a dose and timedependent manner and the cell growth curves were changed accordingly (P
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