美国医学院的申请难度很高，知名医学院每年从所有申请者中挑选15% 左右到学校面试，再从中确定 10% 的录取名单，基本上是“百里挑一”的选拔。熟知美国医学院录取情况的考生往往会同时申请十余所、乃至几十所医学院，以增加被录取的概率。
美国的医学教育很发达，临床医学和基础医学研究在内的医学院一直是美国及世界各地优秀本科生升学深造的热门选择。近年来，美国医学院的申请人数持续上升，竞争非常激烈。
以下2014医学专业大学排名
| 排名 | 学校 | 英文名 | 学费 | 录取人数 | 城市/地区 |
| 1 | 哈佛大学 | Harvard University | $49,875 (full-time) | 700 | Boston, MA |
| 2 | 斯坦福大学 | Stanford University | $47,343 (full-time) | 461 | Stanford, CA |
| 3 | 约翰霍普金斯大学 | Johns Hopkins University | $44,100 (full-time) | 479 | Baltimore, MD |
| 4 | 加州大学旧金山分校 | University of California‒San Francisco | $43,379(full-time) | 648 | San Francisco, CA |
| 4 | 宾夕法尼亚大学 | University of Pennsylvania (Perelman) | $47,090 (full-time) | 646 | Philadelphia, PA |
| 6 | 圣路易斯华盛顿大学 | Washington University in St. Louis | $52,020 (full-time) | 478 | St. Louis, MO |
| 7 | 耶鲁大学 | Yale University | $49,500 (full-time) | 397 | New Haven, CT |
| 8 | 哥伦比亚大学 | Columbia University | $49,504 (full-time) | 662 | New York, NY |
| 8 | 杜克大学 | Duke University | $48,065 (full-time) | 425 | Durham, NC |
| 8 | 芝加哥大学 | University of Chicago (Pritzker) | $44,075 (full-time) | 377 | Chicago, IL |
| 8 | 密歇根大学安娜堡分校 | University of Michigan‒Ann Arbor | $46,944(full-time) | 679 | Ann Arbor, MI |
| 12 | 华盛顿大学 | University of Washington | $56,970(full-time) | 908 | Seattle, WA |
| 13 | 加州大学洛杉矶分校 | University of California‒Los Angeles (Geffen) | $47,029(full-time) | 767 | Los Angeles, CA |
| 14 | 范德堡大学 | Vanderbilt University | $42,750 (full-time) | 444 | Nashville, TN |
| 15 | 加州大学圣地亚哥分校 | University of California‒San Diego | $23,465(full-time) | 520 | La Jolla, CA |
| 16 | 康奈尔大学 | Cornell University (Weill) | $47,150 (full-time) | 409 | New York, NY |
| 16 | 匹兹堡大学 | University of Pittsburgh | $45,846(full-time) | 591 | Pittsburgh, PA |
| 18 | 贝勒医学院 | Baylor College of Medicine | $19,650 (full-time) | 751 | Houston, TX |
| 18 | 西奈山医学院 | Mount Sinai School of Medicine | $41,238 (full-time) | 568 | New York, NY |
| 18 | 西北大学 | Northwestern University (Feinberg) | $48,339 (full-time) | 712 | Chicago, IL |
| 21 | 纽约大学 | New York University | $44,910 (full-time) | 651 | New York, NY |
| 22 | 艾茉莉大学 | Emory University | $46,800 (full-time) | 564 | Atlanta, GA |
| 22 | 北卡罗来纳教堂山分校 | University of North Carolina‒Chapel Hill | $41,786(full-time) | 782 | Chapel Hill, NC |
| 22 | 德克萨斯大学西南医学中心 | University of Texas Southwestern Medical Center | $28,901(full-time) | 939 | Dallas, TX |
| 25 | 凯斯西储大学 | Case Western Reserve University | $51,450 (full-time) | 846 | Cleveland, OH |
| 26 | 弗吉尼亚大学 | University of Virginia | $50,204(full-time) | 614 | Charlottesville, VA |
| 27 | 梅奥医学院 | Mayo Medical School | $35,960 (full-time) | 194 | Rochester, MN |
| 28 | 爱荷华大学 | University of Iowa (Carver) | $47,614(full-time) | 588 | Iowa City, IA |
| 29 | 威斯康辛麦迪逊分校 | University of Wisconsin‒Madison | $33,704(full-time) | 701 | Madison, WI |
| 30 | 波士顿大学 | Boston University | $50,948 (full-time) | 730 | Boston, MA |
| 31 | 布朗大学 | Brown University (Alpert) | $47,480 (full-time) | 452 | Providence, RI |