注射型磷酸钙骨水泥/纤维蛋白胶作为BMP注射性载体的可行性研究
作者：刘通方,刘建,孟国林,袁志,吕荣,毕龙,王登虎,刘艳武,胡蕴玉【关键词】 注射剂；磷酸钙类；骨粘合剂；纤维蛋白组织粘着剂；骨形态发生蛋白质类；载体；骨诱导
【Abstract】 AIM: To evaluate the feasibility of injectable calcium phosphate cement (ICPC) and fibrin sealant (FS) as an injectable compound carrier of bone morphogenic protein (BMP) . METHODS: The composites of ICPC/FS/bBMP, ICPC/FS or bBMP were injected subcutanously or implanted into thigh muscle pouches of 45 mice at random.The effect of ectopic bone formation was evaluated by biochemical examination of alkaline phosphatase (ALP) and histological examination 2 and 4 weeks after operation and the new bones were weighed in the 4th postoperative week to compare statistically the ability of bone formation of different composites. RESULTS: ICPC/FS/bBMP composite induced the formation of new bone most effectively. BBMP stimulated cess osteogenesis while ICPC/FS showed no sign of new bone formation.There was a significant difference among them (P
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